Topiramate and cocaine craving

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August undefined, 2024

WebJan 30, 2016 · Background Topiramate is an anticonvulsant drug and an ideal candidate for reducing the craving in people relying on cocaine. Contingency management is one of the common therapies in the domain of ...

Topiramate for the treatment of methamphetamine addiction: a …

WebThe results found that topiramate provided powerful therapeutic effect with little to no side effects. Individuals in the cocaine rehabilitation process who took topiramate found their … WebNov 3, 2011 · During that period, topiramate did not demonstrate a statistically significant ability to reduce cocaine use. After week eight, topiramate-treated subjects were more likely to be abstinent from cocaine when compared to placebo, as measured by twice-weekly urine benzoylecgonine test (UBT). homes warren county nj

The Neurobiology of Cocaine Dependence and Its Clinical Implications

WebAbstract Aims: Topiramate has shown efficacy at facilitating abstinence from alcohol and cocaine abuse. This double-blind, placebo-controlled out-patient trial tested topiramate … WebTopiramate also was associated, significantly more than placebo, with increasing the likelihood of urinary cocaine-free weeks (16.6% vs 5.8%; odds ratio, 3.21;95% CI, 1.24-8.32; P =.02), as well as decreasing craving and improving observer-rated global functioning (all P <.05). CONCLUSIONS AND RELEVANCE: Topiramate is more efficacious than ... WebCravings for cocaine can be reduced by lowering dopamine levels. This makes topiramate, a GABA-altering medication, a potential treatment for cocaine addiction. This study will … his c0312

Topiramate: Side Effects & Uses in Addiction Treatment

Synaptic mechanisms underlying persistent cocaine craving

WebAmong the most promising medications have been dopamine agonists, including long-acting amphetamine, and modafinil and γ-aminobutyric acid (GABA)/glutamatergic medications … WebObjective: To evaluate anticraving action and tolerability of topiramate in cocaine user treatment. Method: Male users of inhaled cocaine which met criteria for cocaine … homes warren county moWebMar 1, 2007 · Topiramate is an AMPA antagonist that also elevates levels of GABA, which would reduce dopamine and glutamate activity. Topiramate (200 mg/d) improved cocaine abstinence after several weeks of treatment in a recent controlled trial (n = 40), 48 although its effect on cue- induced craving was not measured. homes watermill way

"WebThe anticonvulsant medication topiramate has also proven effective in clinical trials for CUD; topiramate decreased cocaine-positive urine in individuals with CUD in one double-blind... " - Topiramate and cocaine craving

Topiramate and cocaine craving

Topiramate for the treatment of methamphetamine addiction: a …

WebMay 1, 2008 · In animal studies, topiramate reduces cocaine self-administration and the dopaminergic response to cocaine administration and exposure to cocaine-associated cues ... (20–40 mg/d) significantly reduced cocaine craving in cocaine-dependent subjects (Brebner et al., 2002; Ling et al., 1998). The first randomized, double-blind clinical trial ... WebTopiramate also was associated, significantly more than placebo, with increasing the likelihood of urinary cocaine-free weeks (16.6% vs 5.8%; odds ratio, 3.21; 95% CI, 1.24 …

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WebObjective: The purpose of this study was to analyze the effectiveness of topiramate in the treatment of cocaine dependence associated with alcohol consumption and its influence on psychological distress, cocaine and alcohol craving, impulsivity, and self-regulation. WebTopiramate also was associated, significantly more than placebo, with increasing the likelihood of urinary cocaine-free weeks (16.6% vs 5.8%; odds ratio, 3.21; 95% CI, 1.24-8.32; P = .02), as well as decreasing craving and improving observer-rated global functioning (all …

WebMar 15, 2016 · The topiramate group had lower rates of depression and anxiety and a lower relapse rate after four months. 29 However, a randomized trial of 106 patients did not show a difference in alcohol... WebTopiramate is an anticonvulsant and nerve pain medication that was initially developed to treat epileptic seizures. Since then, it has also been used to treat migraines, bipolar disorder, and to help people recover from alcohol, cocaine, and opioid addiction by stabilizing mood, reducing cravings, and preventing seizures during detox.1.

WebMar 23, 2016 · Article Abstract Objective: We performed a double-blind, randomized, placebo-controlled trial to assess the efficacy of topiramate in the treatment of crack cocaine dependence. Method: Sixty men who were dependent on cocaine (DSM-IV) (exclusive use of crack cocaine) were selected. The subjects were randomly assigned to … WebTopiramate was shown to be effective for increasing cocaine abstinence, the proportion of cocaine nonuse days, and the proportion of patients to attain 3 consecutive weeks of …

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WebTopiramate was shown to be effective for increasing cocaine abstinence, the proportion of cocaine nonuse days, and the proportion of patients to attain 3 consecutive weeks of … homes washington state for saleWebCraving decrease with topiramate in outpatient treatment for cocaine dependence: an open label trial. Braz J Psychiatry . 2008;30(2):132-135. doi: 10.1590/S1516 … homes washed away in japanWebMay 6, 2016 · Key Points. Vulnerability to relapse that persists even after prolonged abstinence is a major problem in treating cocaine addiction. Mechanisms underlying this persistent vulnerability can be ... his bzlWebIn addition, a recent study in JAMA Psychiatry demonstrated that topiramate built up over time to a 300 mg maintenance dose helped people who were struggling with cocaine … hisc105WebPreviously, studies found that topiramate could help reduce the use of the drug by users who were not seeking treatment for cocaine addiction. It works by affecting how the brain … his bzWebCocaine cravings are a normal part of the recovery process and are common when a person is withdrawing from an addictive substance such as cocaine. Understanding cravings can … his by king powerWebA double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend 2013; 133:94. Johnson BA, Ait-Daoud N, … homes water st st guilford