Thymocyte selection-associated hmg box
Webb2 mars 1995 · Two candidate genes for controlling thymocyte differentiation, T-cellfactor-1 ( Tcf-1) and lymphoid enhancer-binding factor ( Lef-1 ), encode closely related DNA … Webb7 jan. 2024 · The in vitro-generated exhausted T cells co-express multiple co-inhibitory receptors, including TIM-3, LAG-3, PD-1, and CTLA-4, and upregulate thymocyte selection-associated HMG box protein (TOX) transcription factor, which is critically linked to T cell exhaustion [3, 5, 8].
Thymocyte selection-associated hmg box
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Webb7 maj 2009 · Here, we determined the gene expression signature of peripheral CD8 + T cells undergoing deletional tolerance, relative to those undergoing immunogenic priming or lymphopenia-induced proliferation. From these data, we report the first detailed molecular signature of cells undergoing deletion. Webb11 dec. 2024 · Among them, thymocyte selection–associated HMG-box protein (TOX) was identified as a central transcription regulator in T FH cell development. TOX is highly up-regulated in both mouse and human T FH cells in a BCL6-dependent manner.
Webb22 juli 2024 · In addition, VEGF-A induces thymocyte selection-associated HMG-bOX (TOX)-mediated depletion of cytotoxic T lymphocytes (CTLs) [ 19 ]. TOX is a crucial transcription factor in T cell development and plays a vital role in T cell exhaustion [ 20 ]. Webb22 maj 2024 · Some high-mobility group (HMG) box proteins (e.g., LEF1; 153245) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other …
Webb6 juni 2024 · The paper selection was conducted via PubMed and the listed exclusion criteria were used to obtain relevant publications. The genes from the 10 publications were extracted and categorized in terms of stage and comparator. Figure 2. Differentially expressed genes in mycosis fungoides. Webb24 sep. 2024 · Thymocyte selection-associated high mobility group box protein (TOX) is a 526 aa nuclear protein (molecular weight, 57 kD) that binds DNA in a structure …
Webb19 feb. 2002 · TOX: an HMG box protein implicated in the regulation of thymocyte selection Nature Immunology Published: 19 February 2002 TOX: an HMG box protein …
WebbNX_O94900 - TOX - Thymocyte selection-associated high mobility group box protein TOX - Function. Transcriptional regulator with a major role in neural stem cell commitment and … powell bankingWebb14 feb. 2024 · Using a transgenic screen in zebrafish, thymocyte selection-associated high mobility group box protein (TOX) was uncovered as a collaborating oncogenic driver that accelerated T-ALL onset by ... towel dress for beachWebbClone REA473 recognizes the human and mouse TOX antigen, a member of an evolutionarily conserved DNA-binding protein family, and also known as thymocyte … powell barber shopWebb5 aug. 2024 · Thymocyte selection-associated HMG bOX protein (TOX) is a small family of four proteins, including TOX1 (TOX), TOX2, TOX3, and TOX4. TOX proteins belong to a … powell bart scheduleWebbDescription: Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA. (from RefSeq NM_014729) RefSeq Summary (NM_014729): The protein encoded … powell barnett park seattleWebbthe interest of the researchers: Thymocyte selection-associated HMG-box protein, or short Tox. This name already tells us that it is a high-mobility group-containing transcription factor, and hints at its role in the selection of CD4 T lymphocytes (Aliahmad et al, 2012). During T-cell selection, transient Tox expres- powell bar stoolWebb14 jan. 2008 · We have shown previously that the thymocyte selection–associated HMG box protein (TOX) is transiently up-regulated by calcineurin-mediated TCR signaling in … powell barkhi method