Irs2 cancer

Author: umhl

August undefined, 2024

WebIn colorectal cancer, the up-regulation of DOK5 and IRS2 was associated with overall survival status, while in liver cancer, up-regulation was associated with increased vascular invasion. On the other hand, the up-regulation of different IGF/insulin signaling components can lead to similar clinical outcomes; in colorectal cancer, the up ... WebMar 18, 2024 · Breast cancers that do not express the estrogen receptor (ER) or the progesterone receptor (PR) and have no ERBB2 (commonly referred to as human epidermal growth factor receptor 2 [HER2]) amplification are categorized as triple-negative breast cancers (TNBCs) and comprise 10%–20% of all breast cancers ( Dent et al., 2007, …

IRS2 (insulin receptor substrate 2) - atlasgeneticsoncology.org

http://www.cancerindex.org/geneweb/IRS2.htm WebApr 19, 2024 · The identification of somatic mutations in IRS2 in 29% of PILC samples is the first report of recurrent IRS2 mutation in any subtype of breast cancer to our knowledge. IRS2 is an adaptor protein for the insulin and IGF-1 receptors, and it mediates their … inactive accounts

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WebJun 15, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples showed increased expression of IRS2 protein in BM. WebJul 15, 2013 · IRS2 is associated with cancer cell motility and metastasis. Currently, there are no anticancer agents that target IRS1/2. We present new IGF-IR/IRS-targeted agents (NT compounds) that promote inhibitory Ser-phosphorylation and degradation of IRS1 and IRS2. Elimination of IRS1/2 results in long-term inhibition of IRS1/2-mediated signaling. WebJun 15, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples … inceptionv3模型图

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WebMar 4, 2024 · In addition, it was found that IRS2 silencing had an inhibitory effect on the progression of NSCLC, and the upregulation of IRS2 partially impaired the inhibitory effect of miR‐448 in NSCLC. WebIRS2 mutations identified in pleomorphic invasive lobular carcinoma (PILC) enhance invasion, revealing a role for this signaling adaptor in the aggressive nature of PILC. IRS2 is an adaptor protein that links ALK to neuroblastoma cell survival through the Akt-FoxO3 … inceptionv3结构图WebApr 11, 2024 · The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by cytomegaly, nuclear enlargement, and hyperchromasia of endometrial glands; typically associated with intrauterine or extrauterine pregnancies or with gestational trophoblastic disease. Although differentiating the Arias-Stella reaction (ASR) from clear … inactive account quickbooks online

"WebIRS2 INFORMATION. Proteini. Full gene name according to HGNC. Insulin receptor substrate 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IRS2. Protein classi. Assigned … " - Irs2 cancer

Irs2 cancer

IRS2 protein expression summary - The Human Protein Atlas

WebMay 29, 2015 · In depth analysis revealed that, despite their responses, their tumors demonstrated multiple aberrations in genes including CCND1, CCNE1, FGFR1, MYC, IRS2, MCL1, PIK3CA, PIK3R1, PRKDC, and TP53. The implications of these diverse aberrations for understanding response and resistance are discussed. Case Presentations WebApr 19, 2024 · IRS2 mutations identified in PILC enhance invasion, revealing a role for this signaling adaptor in the aggressive nature of PILC. Invasive breast cancer is a heterogenous disease, with the majority of tumors diagnosed as either invasive ductal carcinoma (IDC; ~80%) or invasive lobular carcinoma (ILC; ~8–14%).

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WebMar 1, 2024 · Thus, our findings suggest that Hippo signaling interacts with AKT signaling by regulating IRS2 expression to prevent NAFLD and liver cancer progression and provide evidence that impaired crosstalk between these 2 pathways accelerates NAFLD and liver … WebIRS2 - Explore an overview of IRS2, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. Projects COSMIC

WebJan 9, 2024 · To investigate the clinical implications of IRS2 gain/amplification in cancer progression, we analyzed the SCLC dataset that is publicly available via the cBioPortal for Cancer Genomics (http://www.cbioportal.org/msk-impact). IRS2 amplification was … WebJul 1, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is known to be involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples showed increased expression of IRS2 protein in BMs.

WebMar 29, 2024 · This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and … WebJan 24, 2024 · Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the malignant ...

WebNov 23, 2016 · IRS1 and IRS2 are the best studied members and are shown to have important roles in cell proliferation, survival, migration, metabolism and differentiation, and have been implicated in cancer...

WebDec 2, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is known to be involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples … inceptionv3模型缺点WebJul 7, 2013 · IRS2 is associated with cancer cell motility and metastasis. Currently there are no anti-cancer agents that target IRS1/2. We present new IGF1R/IRS-targeted agents (NT compounds) that promote inhibitory Ser-phosphorylation and degradation of IRS1 and IRS2. inceptionv3网络结构详解WebApr 9, 2024 · Insulin receptor substrate 2 (IRS2) belongs to the member of IRS family that regulates cell proliferation, apoptosis, and metabolism by functioning as a molecular adaptor to integrate and coordinate extracellular signals from insulin and other ligands to mitochondria (Dearth et al. 2007 ). inactive accounts riskWebJan 9, 2024 · Small cell lung cancer (SCLC) is a fast-growing and malignant cancer that responds well to chemotherapy; however, the survival rate is less than 15% after 2 years of diagnosis. Therefore, novel therapeutic agents for treating SCLC patients need to be evaluated. This study aims to identify the therapeutic targets based on the comprehensive … inactive accounts in netsuiteWebApr 11, 2024 · The mission of the Public Health Genomics is to integrate advances in human genetics into public health research, policy, and programs inceptionv3模型详解WebThe IRS2 GD genotype reduced risk of colon cancer, except among those with an IRS1 R allele. No significant associations were seen in analyses of main effects or interactions of these variants and rectal cancer risk. Conclusions: Both IRS1 and IRS2 variants were associated with colon cancer risk independently. inceptionv3网络模型WebApr 21, 2024 · A total of 205 ERBB2 aberrations were detected in 175 of the 589 breast cancer cases, revealing an ERBB2 mutation rate of 29.7%. Various mutation types detected from our cohort included CN amplification (n=166), missense mutations (n=14), fusion (n=12), synonymous mutations (n=7), splice-site mutations (n=3), and intronic mutations … inceptionv3模型结构图