Hypergastrinemic animal models

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August undefined, 2024

WebRodents frequently used in laboratory investigation include mice, rats, gerbils, hamsters, and guinea pigs. Of these, mice, rats, and Mongolian gerbils are most widely used in … WebIn all species where long-term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common …

Animal Models to Study the Role of Long-Term Hypergastrinemia …

WebIn this animal model it is possible to study the effects of hypergastrinemia without gastric hypoacidity, mimicking human gastrinomas. Young INS-GAS mice have an increased ECL cell number and a proportion of these mice develop adenocarcinomas in the gastric corpus at the end of their lifespan [ 39 ]. WebIn gastric cancer cell lines, gastrin increased secretion of clusterin, and both gastrin and secretory clusterin promoted survival after starvation- and chemotherapy-induced stress. Overall, our results indicate that clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and stimulates gastric cancer cell survival. thomas brock obituary

Animal Models of Gastric Carcinoma SpringerLink

WebThe novel BN/GRP synthetic receptor antagonist, RC-3095, was able to produce long-lasting tumor regressions in murine and human tumor models in vitro and in vivo. Animal toxicology studies showed no detectable organ toxicity apart from local irritation at the injection site. The purpose of this… Exibir mais ABSTRACT: WebMale hypergastrinemic transgenic (INS-GAS) mice with 6-months H. felis infection were compared with three different age, strain and gender-matched control groups: (i) INS … WebThe common mechanism observed in both the hypergastrinemic mouse model and human carcinoids is translocation of the cyclin-dependent inhibitor p27 kip to the cytoplasm and … thomas broderick md lake mary fl

The cytoprotective protein clusterin is overexpressed in ...

Web30 jun. 2024 · These effects have repeatedly been shown to result in ECL carcinoids and / or adenocarcinomas in animal models of long-term hypergastrinemia (Waldum et al., 2004). Zollinger Ellison syndrome (gastrinoma) and pernicious anaemia (chronic atrophic gastritis) represent models of hypergas- trinemia in man. WebBackground & Aims: Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has not been fully explo… thomas brochet facebookWebStarting at 12 months of age, animals were randomized to treatment with the proton pump inhibitor lansoprazole or vehicle by gavage for 6 months. At autopsy, pancreatic wet … thomas broady alumasc

"Web1 jan. 2000 · The 2 hypergastrinemic models differ in the strains of mice used, as well as in the presence of acid in the early stages; further work is now needed to establish the … " - Hypergastrinemic animal models

Hypergastrinemic animal models

AnimalModelstoStudytheRoleofLong-TermHypergastrinemia ...

WebSerum gastrin concentrations increased three- to fivefold in fasting and fed antral implant animals. Serum gastrin levels in the fed state were lower in antrectomy rats compared to controls but did not differ in the fasting rats. Pancreas and colon were heavier in all hypergastrinemic rats. Web1 apr. 2002 · In a different study, a duodenogastric reflux model led to elevated gastrin levels and similar results in azaserine-treated animals [33]. A gastrin receptor agonist …

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Web7 jan. 2024 · With non-human primates usually being excluded for ethical, regulatory or financial reasons, dogs, pigs, and sheep have been the most frequently used large animal species in cardiovascular research. 9. Although undoubtedly a sound model for certain cardiovascular diseases (i.e. arrhythmias or pacemaker studies) in the past, dogs are … WebBackground: As many as 24% of patients who undergo endoscopic sphincterotomy for the removal of bile duct stones have recurrent biliary complications develop for which there is no effective method of prevention. The aim of this study was to determine whether patients who undergo routine clinical follow-up after endoscopic sphincterotomy for bile duct stones …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebAnimal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis Reidar Fossmark,1,2 Gunnar Qvigstad,1,2 Tom Chr. Martinsen,1,2 0yvind Hauso,1,2 and Helge L. Waldum1,2 1 Department of Gastroenterology and Hepatology, St. Olavs Hospital HF, Trondheim University Hospital, 7006 Trondheim, Norway

Web31 aug. 2010 · Animal Models to Study the Role of Long-Term Hypergastrinemia in Gastric Carcinogenesis Patients with chronic hypergastrinemia due to chronic atrophic gastritis … WebAnimal models are an indispensable resource for investigating the causes of gastric cancer, ... A notable exception is male-predominant disease expression in hypergastrinemic INS-GAS mice on the FVB strain background (Fox, Rogers et al. 2003; Fox, Wang et al. 2003).

Web1 jan. 2000 · The phenotype in hypergastrinemic transgenic mice is distinct from that in rats with References (46) VD Huebner et al. Purification and structural characterization of …

WebPatients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused by long-term use of acid uec formationWebHypergastrinemic animals develop ECL cell derived gastric carcinomas located in the oxyntic mucosa, thus being an interesting animal model for studying the role of gastrin … thomas broderick cardiologistWeb5 nov. 2024 · Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 975479, 6 pages doi:10.11552011975479 Review Article Animal Models to Study… thomas broderick md cincinnatiWeb1 jan. 2011 · Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of … uec finance yahooWebwere recently studied using hypergastrinemic animal models. Wang et al. (45) produced transgenic (TG) mice expressing gastrin under the control of an insulin pro-moter, which … uechi ryu karate books and dvdsWebHypergastrinemia causes carcinoids or carcinomas in the gastric corpus in animal models. Helicobacter pylori (HP) infection in patients causes atrophy, hypergastrinemia and … uechi ryu historyWeb1 jan. 2002 · Abstract Hypergastrinemia and a reduction in tissue somatostatin occur in Helicobacter pylori -infected patients. We investigated whether the D cell may be a direct target of gastric inflammation and hypergastrinemia. D cells were quantified by morphometry and flow cytometry in 16-wk-old wild-type (G+/+) and gastrin-deficient (G−/−) mice. … ue cheap speakers