Cytidine analogs
Webnucleotide analogue triphosphates (2 to 6 h) [7]. At higher concentrations the elimination kinetics becomes biphasic and the terminal half-life is very long. On the other hand, GEM has a very short plasma half-life because it is rapidly eliminated by cytidine deaminase, which is located not only in blood cells and plasma but also in large body ... WebThe transport of cytidine into the brain extracellular fluid, and then into neurons and glia, is an essential prerequisite for cytidine to be utilized in the brain [103]. The nucleoside analogs, including cytidine analogs, are often used in cancer chemotherapy. They belong to an important group of drugs, which are antimetabolites.
Cytidine analogs
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WebWhen these analogs are integrated into growing DNA strands, some, including 5-azacytidine, severely inhibit the action of the DNA methyltransferase enzymes that … WebOct 16, 2024 · Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation …
WebTroxacitabine (BCH-4556; (−)-2-(S)-hydroxymethyl-4-(s)-(cytosin-1′-yl)-1,3-dioxolane; β-L-dioxalane cytidine) is a stereochemically synthetic nucleoside analogue that has potent antitumor ... WebJul 6, 2024 · interaction of cytidine analogs with the receptor protein. The pharmacokinetic prediction was obtained to calculate the absorption, metabolism, and toxicity of the …
WebJun 22, 2015 · ALS-8176 and its parent cytidine analog ALS-8112 were recently discovered to be potent inhibitors of RSV replication in vitro . In clinical trials, ALS-8176 given orally was efficacious against RSV infection in adult volunteers . In this paper, we present the mechanism of action and the antiviral selectivity of ALS-8176 and ALS-8112. WebThe pyrimidine analogs are S-phase-specific drugs that include fluorouracil and cytarabine. Fluorouracil is a fluorinated pyrimidine that becomes phosphorylated intracellularly and then binds covalently with thymidylate synthetase, thereby inhibiting its action and interfering with DNA and RNA synthesis (see Fig. 2.8) [8, 21].There is little evidence that fluorouracil has …
WebMay 14, 2024 · Stavudine ( 46 ), approved for use in 1994, became the fourth drug among nucleoside analogs for the treatment of HIV infection. 2, 4 Cytidine analog of stavudine ( 46 ), 3'-dideoxy-2',3'-didehydrocytidine ( 47 ), has approximately the same activity against HIV (EC 50 0.009 and 0.005 μM, respectively 22 ).
WebSelection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene . × Close Log In. Log in with Facebook Log in with … open vs closed form filmWebMay 1, 1980 · Three other analogs of cytidine, containing a modification in the 5 position of the pyrimidine ring [5-aza-2′-deoxycytidine(5-aza-CdR), pseudoisocytidine (ψICR) and … ipd wholesalerWebNational Center for Biotechnology Information open vs closed ecosystemsWebThree other analogs of cytidine, containing a modification in the 5 position of the pyrimidine ring [5-aza-2'-deoxycytidine (5-aza-CdR), pseudoisocytidine (psi ICR) … open vs closed class wordsWebIntroduction: RX-3117 is an oral, small molecule cytidine analog anticancer agent with an improved pharmacological profile relative to gemcitabine and other nucleoside … open vs. closed circulatory systemWebFeb 1, 2015 · Synthesis of carbocyclic 5'-nor uridine and cytidine derivatives Carbocyclic 5'-nor uridine and cytidine derivatives were synthesized. Carbocyclic 5'-nor uridine and cytidine derivatives were synthesized. Synthesis of carbocyclic 5'-nor uridine and cytidine derivatives Nucleic Acids Res Suppl. 2002;(2):15-6.doi: 10.1093/nass/2.1.15. Authors open vs closed environmentWebCytidine Deaminase (CDA or CDD) Cytidine deaminase is a key enzyme involved in the pyrimidine salvage pathway and maintains the cellular pyrimidine supply. It is encoded by the human CDA gene. In the 1960s, cytosine nucleoside analogs, such as cytarabine, were reported to contain antitumor effects. open vs closed fracture of pelvis